Galderma to Share Latest Data Demonstrating High Aesthetic Improvement and Patient Satisfaction Across Its Innovative Portfolio

Zug, Switzerland:

• Galderma will share exciting results from the Sculptra^® Cheek Wrinkle study showing the long-lasting effectiveness and safety of Sculptra, as well as high aesthetic improvement and patient satisfaction over two yearsⁱ
• The company will also present 10 research posters, including positive outcomes from the Alluzience^® STAR study. This study shows high patient satisfaction and investigator preference for Alluzience over powder solutions and long duration of effect at six monthsⁱⁱ
• Two symposia will build on Galderma’s Holistic Individualized Treatment (HIT^™) approach through programs Kiss & Smile^™ and Balanced Profile^™, and on another new solution offering an innovative long-term treatment approach

Galderma will be showcasing the latest updates from across its portfolio at the International Master Course on Aging Science (IMCAS) World Congress 2023 in Paris from January 26-28, 2023. Events will include several ‘meet the expert’ sessions and interactive booth activities. In addition, Galderma will share 10 research posters and host two symposia, featuring data from its broad, highly differentiated portfolio of neuromodulators, biostimulators and fillers. Presenters and contributors will draw from the company’s research into serious skin conditions, such as rosacea and actinic keratosis.

Galderma is the only pure-play dermatology category leader, with more than 40 years of heritage in dermatology. Its significant presence at IMCAS underscores its commitment to delivering science, innovation and a premium experience for physicians, consumers and patients throughout the treatment journey. Galderma is a leader in bringing cutting-edge products to market and in providing the scientific community with individualized treatment approaches, training and business support.

Presenting the latest in clinical findings and educational efforts

Galderma will be sharing important data at IMCAS on Sculptra^® (injectable poly-L-lactic acid, PLLA-SCA). This is the first and only U.S. Food and Drug Administration (FDA)-approved PLLA facial injectable treatment that helps stimulate the skin’s type I collagen production.^iii,iv Sculptra helps restore fullness and firmness to areas of the face that become loose or saggy. The results of the innovative Sculptra Cheek Wrinkle study, which were measured using state-of-the-art technology, show the early onset, long-lasting effectiveness and safety of the treatment for cheek wrinkle correction over 24 months. These findings were complemented by high aesthetic improvement, high subject satisfaction with cheek appearance, and improvement in skin quality parameters including radiance and skin firmness (tightness) after treatment.ⁱ

Additional exciting data will be presented for Galderma’s neuromodulators, in particular for Alluzience^® (abobotulinumtoxinA solution), including the latest data from Alluzience’s first phase IV study, STAR. Approved in Europe in June 2021, Alluzience is Europe’s first ready-to-use liquid neuromodulator for the treatment of moderate to severe glabellar lines (frown lines). Results from the unique STAR study show high patient satisfaction, with most investigators preferring Alluzience to powder solutions. Both investigators and patients also reported long-duration aesthetic improvement following a six-month follow-up period.ⁱⁱ

Galderma’s symposia at IMCAS highlight its dedication to providing not only innovative products but also cutting-edge approaches to support physician assessment and technique.

The first symposium builds on Galderma’s Holistic Individualized Treatment (HIT™) series with a focus on two new programs: HIT Kiss & Smile™ and Balanced Profile™.HIT is a patient-centric, science-based, individualized treatment approach that enables injectors to leverage their expertise with the renowned Galderma portfolio and optimize aesthetic outcomes while prioritizing patient satisfaction. The event is taking place in the Amphitheatre Bleu, Level 2 on Friday, January 27, from 8:30 to 10:00 AM CET.

The second symposium, Our Aesthetic Lives: A long-term journey into aesthetic treatments, will deep-dive into the aesthetic lives of patients and the medical professionals who treat them as they shape the future of this field. It will take place in the Amphitheatre Bleu, Level 2 on Friday, January 27, from 4:00 to 6:00 PM CET.

Showcasing cutting-edge research with 10 research posters

Neuromodulators

Galderma will be sharing several updates on its neuromodulators, Alluzience and Azzalure^® (abobotulinumtoxinA), including:

• Ready-to-use abobotulinumtoxinA solution versus powder onabotulinumtoxinA for treating glabellar lines: Subjects’ and Investigators’ experiences ⁱⁱ
• Subject and physician satisfaction with abobotulinumtoxinA for glabellar line treatment in a real-world study in Chinese subjects^v
• How glabellar line severity at baseline can affect efficacy in neurotoxin trials^vi

Biostimulators

Posters on Sculptra, the first and only U.S. FDA-approved PLLA facial injectable treatment, include:

• Effectiveness and safety of cheek wrinkle correction using a biostimulatory poly-L-lactic acid injectable implant – clinical study data up to 24 months ⁱ
• Product manufacturing process for poly-L-lactic acid (PLLA-SCA)^vii
• Skin movement and volume changes with poly-L-lactic acid (PLLA-SCA) injectable implant: a subgroup analysis of the cheek wrinkle trial^viii

Fillers

Galderma will also be sharing the latest data on its portfolio of fillers, including Restylane^® Defyne for chin. Restylane Defyne has demonstrated results across a wide range of participants, including participants with all skin types, males, and those over the age of 52.^ix Posters include:

• Improvement of chin retrusion in Chinese subjects using a hyaluronic acid filler: a randomized, controlled, evaluator-blinded study^x
• Differentiation of NASHA^TM and OBT ^TM hyaluronic acid gels according to firmness and flexibility and associated clinical significance^xi

Actinic keratosis and rosacea

For decades, Galderma has been researching these serious and often severe skin conditions that affect a significant cross-section of society, reflecting its expertise and demonstrating its commitment to advancing dermatology for every skin story. Posters include:

• Cosmetic outcomes in patient-centered management of AK – Personalizing Actinic Keratosis Treatment (PAKT) expert consensus^xii
• A customized skin care routine benefits patients with severe rosacea under combination therapy with ivermectin 1% cream and doxycycline 40-mg or ivermectin and placebo^xiii